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Paul D. Adams
Acting Division Director, Physical Biosciences, Lawrence Berkeley Laboratory
Senior Scientist, Lawrence Berkeley Laboratory
Adjunct Professor, Dept. Bioengineering, U.C. Berkeley
Head, Berkeley Center for Structural Biology
Director, Computational Crystallography Initiative
Vice President for Technology, the Joint BioEnergy Institute
Investigator, Energy Biosciences Institute
Office: Building 64, Room 248, Lawrence Berkeley Laboratory
Email: PDAdams@lbl.gov or pdadams@berkeley.edu
Phone: 510-486-4225
Fax: 510-486-5909
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Computational Methods Development
Much of my research is focused on the development of new algorithms and methods for
addressing problems in structural biology. In collaboration with
researchers from Los Alamos National Lab, Duke University and
Cambridge University we are developing a new software system with NIH
Program Project funding, called PHENIX, for the automated
solution of macromolecular structures using crystallographic
methods. With other NIH funding we are also pursuing projects that
expand the scope of PHENIX to include the analysis of neutron
diffraction data, and single particle
cryo-EM reconstruction methods.
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Synchrotron Resources for Structural Biology
As Head of the Berkeley Center for
Structural Biology I oversee the development, maintenance and
operation of five synchrotron beamlines for macromolecular
crystallographic data collection. We are constantly upgrading the
facilities to provide researchers with the best tools for data
collection and structure solution. An area of particular interest to
me is the structural study of large
macromolecular machines combining multiple experimental and
computational methods.
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Bioenergy Research
Global warming has become a major world issue and carbon dioxide gas
emissions from the burning of fossil fuels are a significant
contributor to the problem. The need to develop carbon-neutral and
renewable sources of energy has become a priority. The conversion of
cellulosic (plant) material to fuels such as ethanol has the potential
to provide a significant fraction of fuel in the future. As part of
the Joint Bioenergy Institute I am
developing new technologies to improve the conversion of biomass to
fuels. As part of the Energy Biosciences
Institute I am collaborating with others to develop new methods
for the chemical imaging of plant call wall material
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